TJENG Volume 2018

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Modeling dynamic behavior of striatal medium spiny neurons with point neuron models

Yüksel Çakır
Keywords: straitum, medium spiny neurons, Hodgkin-Huxley neuron model, Izhikevich model
The aim of this work is to investigate the role of network organization and the neuron model type on the collective dynamic behavior of striatal population. For that purpose, two different scale neuron models which are phenomenological Izhikevich and conductance-based Hodgkin-Huxley (HH) type are used to investigate the dynamic behavior of MS neurons. Two network architectures are proposed with inhibitory and excitatory synaptic currents. In these networks, while all MS neurons affect each other with inhibitory synaptic currents, an excitatory current is applied to all MS neurons in the first layer, to represent the cortical inputs. A mathematical model of a medium spiny neuron of striatum based on HH type neuron model is proposed using different calcium channels and its dynamical behavior is investigated. It is observed that when the original HH model is used, regular spiking type behavior is observed. Including the high threshold calcium current, after hyperpolarization calcium current and voltage gated potasium current into the model improves the modeling capabilities. With extended ion channels, in addition to regular spiking behavior, bursting with resting stage are obtained. Then, Izhikevich neuron model is used in the network structures to compare the dynamic behaviors and computational time.


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